I-Aminoguanidine Hydrochloride
Igama lomkhiqizo:carbazamidine hydrochloride; (diaminomethylidene) i-hydrazinium chloride
Ifomula Yamamolekhula:CH6N4HCL
CAS:1937-19-5
Isisindo Yamamolekhula:110.55
Ifomula Yesakhiwo:
Sebenzisa:Ezemithi, izidakamizwa zezilwane
|
Inkomba igama |
Inani Lenkomba |
|
|
Ukubukeka |
Mhlophe njengempuphu yekristalu |
|
|
Okuqukethwe |
≥98% |
≥99% |
|
Izinto Ezingaxazululeki |
≤0.2% |
≤0.1% |
|
Ukulahlekelwa Kokomiswa |
≤1.5% |
≤1% |
|
Izinsalela Zokushisa |
≤0.2% |
≤0.1% |
|
Okuqukethwe kwe-Iron (Fe) |
10 ppm |
6 ngomzuzu |
|
Mahhala Acid |
≤0.8% |
≤0.5% |
ukulungiselela
Ukulungiswa kwe-aminoguanidine hydrochloride: i-9 g ye-aminoguanidine carbonate yafakwa ku-250ml three flask port, i-20ml ye-ethanol ngokuphelele yangezwa, okuqinile kwakungancibiliki ku-ethanol engenamanzi ukwakha ukumiswa. Ngaphansi kokunyakaziswa ekamelweni lokushisa, ingxube ye-6ml 30% egxilile i-hydrochloric acid kanye ne-10ml ye-ethanol ephelele yengezwa nge-dropwise kuze kube kungekho bubble, bese ukushukumisa ukuphendula kwaqhubeka ekamelweni lokushisa ihora elilodwa. Ukumiswa okutholakele kwafudunyezwa ukuze kuqedwe ngokuphelele okuqinile, bese kwehliswa ngokwemvelo ekamelweni lokushisa. Ngemuva kokuhanjiswa esiqandisini futhi ibekwe ubusuku bonke, ikristalu elimhlophe elimise okwentonga elinendawo yokuncibilika ka-166-167℃ itholakele.
Isicelo
UDaidzein unemiphumela ehlukahlukene yokwenziwa kwemithi, ukuvimbela nokwelashwa kwezifo ezahlukahlukene. I-Cn200910144204.1 ibike ukuthi i-aminoguanidine hydrochloride ingasetshenziselwa ukulungisa i-daidzein eguqulwe ngamakhemikhali, okuyi-daidzein 7,4 '- oxy aminoguanidine acetate. I-soybean aglycone 7,4 '- oxy aminoguanidine acetate iyinhlanganisela yeprodrug, ekhipha umuthi ongumzali - i-daidzein ngaphansi kwezimo zomzimba, futhi ithuthukise ukuncibilika kwamanzi ngokubopha okuhlanganayo.
Ukulungiswa kweDaidzein 7,4 ′ - o-aminoguanidine acetate: 0.5g aminoguanidine hydrochloride yachithwa ku-100ml acetone, 0.02g phase phase transfer catalyst, 0.5g anhydrous potassium carbonate, 0.5g 7,4 ′ - I-chloroacetyl daidzein kanye ne-0.02g I2 kungezwe esisombululo. Ukusabela kwenziwa ekamelweni lokushisa amahora angama-24. I-Acetone yahwamuka kusukela ku-filtrate ngaphansi kwengcindezi encishisiwe, bese ihlukaniswa yikholamu ye-silica gel. I-eluent kwakuyi-ethyl acetate∶ i-petroleum ether Lapho isilinganiso singu-1 ∶ 2, i-powder emhlophe eqinile iyatholakala.